Improvement of Tomato bushy stunt virus-based vectors for fusion and non-fusion expression of heterologous proteins in an alternate host Nicotiana excelsiana

Plant virus-based expression methods are an alternate expression platform for the manufacturing of clinically and industrially helpful recombinant proteins. Nonetheless, because of an absence of viral vector with the industrial potentials, it’s pressing to design and develop new, versatile, and environment friendly plant virus vectors.

The genome of Tomato bushy stunt virus (TBSV) affords a lovely different to being modified as a vector for producing heterologous proteins in crops. Right here, we developed a set of novel fusion and non-fusion TBSV-CP alternative vectors, which offer extra versatile and environment friendly instruments for expressing proteins of curiosity in crops. Another tobacco plant, Nicotiana excelsiana, was used on this examine as a bunch for newly constructed TBSV vectors as a result of the undesirable necrotic results have been reported on the generally used Nicotiana benthamiana host related to expression of TBSV-encoded P19 protein.

The information confirmed that TBSV vectors prompted a symptomless an infection and overexpressed reporter gene in N. excelsiana leaves, demonstrating that N. excelsiana is a perfect host plant for TBSV-mediated heterologous gene expression. Furthermore, a TBSV non-fusion vector, dAUG, exhibits the same accumulation stage of reporter proteins to that of TMV- and PVX-based vectors in side-by-side comparability and gives extra versatile elements than the beforehand developed TBSV vectors. Collectively, our newly developed TBSV expression system provides a new member to the household of plant viral expression vectors and in the meantime affords a versatile and extremely efficient strategy for producing proteins of curiosity in crops.

KEY POINTS:

• The TBSV-based transient expression system has been considerably improved.

• The necrotic results brought on by viral P19 protein have been prevented by the utilization of N. excelsiana as a bunch plant.

• The expression stage of the non-fusion vector was much like the best virus vectors reported to date.

Mouse Anti Human CD163: RPE
MBS225636-100Tests	MyBiosource	100Tests	EUR 520

Mouse Anti Human CD163: RPE
MBS225636-5x100Tests	MyBiosource	5x100Tests	EUR 2160

MOUSE ANTI HUMAN CD163: FITC
MBS225948-01mg	MyBiosource	0.1mg	EUR 435

MOUSE ANTI HUMAN CD163: FITC
MBS225948-5x01mg	MyBiosource	5x0.1mg	EUR 1785

Human CD163 antigen(CD163)ISA kit
GA-E0263HM-48Tests	GenAsia Biotech	48 Tests	Ask for price

Human CD163 antigen(CD163)ISA kit
GA-E0263HM-96Tests	GenAsia Biotech	96 Tests	EUR 388

Human CD163 antigen(CD163)ISA kit
GA-E0263HM-48T	GenAsia Biotech	48T	EUR 346.8

Human CD163 antigen(CD163)ISA kit
GA-E0263HM-96T	GenAsia Biotech	96T	EUR 559.2

Human CD163 antigen(CD163)ISA kit
QY-E05066	Qayee Biotechnology	96T	EUR 433.2

human CD163 antigen,CD163 LISA kit
201-12-0247	Shanghai Sunred Biological Technology	96 tests	EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

human CD163 antigen,CD163 ELISA kit
YLA0098HU-48T	Shanghai YL Biotech	48T	Ask for price

human CD163 antigen,CD163 ELISA kit
YLA0098HU-96T	Shanghai YL Biotech	96T	Ask for price

Human CD163 antigen,CD163 ELISA KIT
E0246Hu-1096T	Jiaxing Korain Biotech Ltd (BT Labs)	10*96T	EUR 4122

Human CD163 antigen,CD163 ELISA KIT
E0246Hu-48wells	Jiaxing Korain Biotech Ltd (BT Labs)	48 wells	EUR 300

Human CD163 antigen,CD163 ELISA KIT
E0246Hu-596T	Jiaxing Korain Biotech Ltd (BT Labs)	5*96T	EUR 2061

Human CD163 antigen,CD163 ELISA KIT
E0246Hu-96wells	Jiaxing Korain Biotech Ltd (BT Labs)	96 wells	EUR 458

Human CD163 Antigen (CD163) ELISA Kit
MBS9353075-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 6725

Human CD163 Antigen (CD163) ELISA Kit
MBS9353075-48StripWells	MyBiosource	48-Strip-Wells	EUR 550

Human CD163 Antigen (CD163) ELISA Kit
MBS9353075-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3420

Human CD163 Antigen (CD163) ELISA Kit
MBS9353075-96StripWells	MyBiosource	96-Strip-Wells	EUR 765

Human CD163 antigen, CD163 ELISA Kit
MBS165165-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 3460

Human CD163 antigen, CD163 ELISA Kit
MBS165165-48StripWells	MyBiosource	48-Strip-Wells	EUR 285

Human CD163 antigen, CD163 ELISA Kit
MBS165165-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 1750

Human CD163 antigen, CD163 ELISA Kit
MBS165165-96StripWells	MyBiosource	96-Strip-Wells	EUR 425

Human CD163 Antigen, CD163 GENLISA ELISA
KBH0246	Krishgen	1 x 96 wells	EUR 286

Mouse Anti Human Cd163 Monoclonal Antibody
CABT-47162MH	Creative Diagnostics	25 µg	EUR 446.4

Mouse Anti Human Cd163 Monoclonal Antibody
CABT-47163MH	Creative Diagnostics	0.2 mg	EUR 1057.2

Mouse Anti Human CD163, APC Conjugated mAb
MBS9431893-100Tests	MyBiosource	100Tests	EUR 520

Mouse Anti Human CD163, APC Conjugated mAb
MBS9431893-25Tests	MyBiosource	25Tests	EUR 275

Mouse Anti Human CD163, APC Conjugated mAb
MBS9431893-5x100Tests	MyBiosource	5x100Tests	EUR 2195

CD163 (untagged)-Human CD163 molecule (CD163), transcript variant 2
SC308167	Origene Technologies GmbH	10 µg	Ask for price

CD163 (untagged)-Human CD163 molecule (CD163), transcript variant 1
SC117495	Origene Technologies GmbH	10 µg	Ask for price

PE anti-human CD163
E16FHP163-025	EnoGene	25 tests	EUR 433.33
Description: Available in various conjugation types.

PE anti-human CD163
E16FHP163-100	EnoGene	100 tests	EUR 953.33
Description: Available in various conjugation types.

Anti-Human CD163 PE
MBS696987-100Tests	MyBiosource	100Tests	EUR 415

Anti-Human CD163 PE
MBS696987-25Tests	MyBiosource	25Tests	EUR 225

Anti-Human CD163 PE
MBS696987-5x100Tests	MyBiosource	5x100Tests	EUR 1820

Anti-Human CD163 Antibody
101-M291	ReliaTech	100 µg	EUR 399
Description: CD163, also known as hemoglobin scavenger receptor, is a type I transmembrane protein expressed exclusively in monocytes and macrophages. It is a scavenger receptor cysteine-rich superfamily (SRCR-SF) protein that contains nine SRCR motifs in its extracellular region. Two alternatively spliced cytoplasmic variants of human CD163 exist. A soluble form of CD163 can also be released by metalloproteinase-mediated shedding of the extracellular domain. CD163 mediates the endocytosis of haptoglobin-hemoglobin complexes.

APC anti-human CD163
E16FHA163-025	EnoGene	25 tests	EUR 520
Description: Available in various conjugation types.

APC anti-human CD163
E16FHA163-100	EnoGene	100 tests	EUR 1191.67
Description: Available in various conjugation types.

Anti-Human CD163 APC
MBS696989-100Tests	MyBiosource	100Tests	EUR 480

Anti-Human CD163 APC
MBS696989-25Tests	MyBiosource	25Tests	EUR 245

Anti-Human CD163 APC
MBS696989-5x100Tests	MyBiosource	5x100Tests	EUR 2115

APC anti-human CD163
MBS9459445-100Tests	MyBiosource	100Tests	EUR 655

APC anti-human CD163
MBS9459445-25Tests	MyBiosource	25Tests	EUR 355

APC anti-human CD163
MBS9459445-5x100Tests	MyBiosource	5x100Tests	EUR 2790

FITC anti-human CD163
E16FHF163-025	EnoGene	25 tests	EUR 520
Description: Available in various conjugation types.

FITC anti-human CD163
E16FHF163-100	EnoGene	100 tests	EUR 1191.67
Description: Available in various conjugation types.

Biotin anti-human CD163
E16FHB163-025U	EnoGene	25 μg	EUR 346.67
Description: Available in various conjugation types.

Biotin anti-human CD163
E16FHB163-100U	EnoGene	100 μg	EUR 780
Description: Available in various conjugation types.

Purified anti-human CD163
E16FHU163-100U	EnoGene	100 μg	EUR 433.33
Description: Available in various conjugation types.

CD163 (GFP-tagged) - Human CD163 molecule (CD163), transcript variant 2
RG212754	Origene Technologies GmbH	10 µg	Ask for price

CD163 (GFP-tagged) - Human CD163 molecule (CD163), transcript variant 1
RG208557	Origene Technologies GmbH	10 µg	Ask for price

Rabbit Anti Human CD163 Monoclonal Clone ABCC-3
IRBAHUCD163ABCC3C100UL	Innovative research	each	EUR 496
Description: Rabbit Anti Human CD163 Monoclonal Clone ABCC-3

Recombinant Human CD163/CD163 Protein, His Tag
E40KMH346	EnoGene	20ug	EUR 495

CD163 (Myc-DDK-tagged)-Human CD163 molecule (CD163), transcript variant 1
RC208557	Origene Technologies GmbH	10 µg	Ask for price

CD163 (Myc-DDK-tagged)-Human CD163 molecule (CD163), transcript variant 2
RC212754	Origene Technologies GmbH	10 µg	Ask for price

Human CD163 Protein
E40KMPH6242	EnoGene	20ug	EUR 495

Recombinant Human CD163
MBS147285-0001mg	MyBiosource	0.001mg	EUR 240

Recombinant Human CD163
MBS147285-0005mg	MyBiosource	0.005mg	EUR 310

Recombinant Human CD163
MBS147285-005mg	MyBiosource	0.05mg	EUR 1360

Recombinant Human CD163
MBS147285-5x005mg	MyBiosource	5x0.05mg	EUR 5800

CD163 siRNA (Human)
MBS8229683-15nmol	MyBiosource	15nmol	EUR 405

CD163 siRNA (Human)
MBS8229683-30nmol	MyBiosource	30nmol	EUR 565

CD163 siRNA (Human)
MBS8229683-5x30nmol	MyBiosource	5x30nmol	EUR 2450

Anti-Human CD163 Antibody (M130)
MBS1564482-01mg	MyBiosource	0.1mg	EUR 340

Anti-Human CD163 Antibody (M130)
MBS1564482-5x01mg	MyBiosource	5x0.1mg	EUR 1235

Anti-Human CD163 Antibody (AB101)
MBS1570008-01mg	MyBiosource	0.1mg	EUR 405

Anti-Human CD163 Antibody (AB101)
MBS1570008-5x01mg	MyBiosource	5x0.1mg	EUR 1520

PE-Cy7 anti-human CD163
E16FHN163-025	EnoGene	25 tests	EUR 650
Description: Available in various conjugation types.

PE-Cy7 anti-human CD163
E16FHN163-100	EnoGene	100 tests	EUR 1408.33
Description: Available in various conjugation types.

APC-Cy7 anti-human CD163
E16FHO163-025	EnoGene	25 tests	EUR 650
Description: Available in various conjugation types.

APC-Cy7 anti-human CD163
E16FHO163-100	EnoGene	100 tests	EUR 1408.33
Description: Available in various conjugation types.

PerCP-Cy5.5 anti-human CD163
E16FHS163-025	EnoGene	25 tests	EUR 541.67
Description: Available in various conjugation types.

PerCP-Cy5.5 anti-human CD163
E16FHS163-100	EnoGene	100 tests	EUR 1278.33
Description: Available in various conjugation types.

Anti-Human CD163 PE-Cyanine7
MBS696988-100Tests	MyBiosource	100Tests	EUR 505

Anti-Human CD163 PE-Cyanine7
MBS696988-25Tests	MyBiosource	25Tests	EUR 270

Anti-Human CD163 PE-Cyanine7
MBS696988-5x100Tests	MyBiosource	5x100Tests	EUR 2220

Mouse Monoclonal anti-human CD163
hAP-0161	Angio Proteomie	100ug	EUR 250

Mouse Monoclonal anti-human CD163
hAP-0161A	Angio Proteomie	50ug	EUR 400

Human, Rat, Mouse CD163 antibody
P0405	Omnimabs	100ul	EUR 150

Human CD163, Fc Tag
E24PHA282	EnoGene	50 μg	EUR 250

Human CD163, His Tag
E24PHA281	EnoGene	50 μg	EUR 250

Human CD163 ELISA Kit
EK5296	SAB	96 tests	EUR 599

Human CD163 ELISA Kit
ELI-05603h	Nova Lifetech	96tests	EUR 696

Human CD163 ELISA Kit
ELA-E1726h	Nova Lifetech	96tests	EUR 696

Human CD163 ELISA Kit
GWB-SKR207	GenWay Biotech	96 Tests	Ask for price

Human CD163 ELISA Kit
LF-EK50890	Abfrontier	1×96T	EUR 777.6

Human CD163 ELISA Kit
MBS824474-5x96Tests	MyBiosource	5x96Tests	EUR 2880

Human CD163 ELISA Kit
MBS824474-96Tests	MyBiosource	96Tests	EUR 645

Human CD163 ELISA Kit
MBS3800092-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 6725

Human CD163 ELISA Kit
MBS3800092-48StripWells	MyBiosource	48-Strip-Wells	EUR 550

Human CD163 ELISA Kit
MBS3800092-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3420

Human CD163 ELISA Kit
MBS3800092-96StripWells	MyBiosource	96-Strip-Wells	EUR 765

Human CD163 shRNA Plasmid
20-abx956176	Abbexa	Ask for price Ask for price	150 µg 300 µg

Human CD163 Protein Lysate
MBS138999-002mg	MyBiosource	0.02mg	EUR 365

Human CD163 Protein Lysate
MBS138999-5x002mg	MyBiosource	5x0.02mg	EUR 1410

Recombinant Human CD163 Protein
RP02295	Abclonal	500μg	EUR 1625

Human CD163 Recombinant Protein
PROTQ86VB7	BosterBio	10ug	EUR 350
Description: Human CD163 Recombinant Protein expressed in Baculovirus with His-tag. Sequence domain: 42-1050aa. Application(s): SDS-PAGE. Endotoxin: < 1 EU per 1ug of protein (determined by LAL method).

CD163 (Human) ELISA Kit
EKA52023-5x96T	Biomatik Corporation	5x96T	Ask for price

CD163 (Human) ELISA Kit
EKA52023-96T	Biomatik Corporation	96T	EUR 446.9

Human CellExp? CD163, Human recombinant
9226-10	Biovision	each	EUR 366

Human CellExp? CD163, Human recombinant
9226-50	Biovision	each	EUR 927.6

anti- CD163/M130 Antibody
FNab09771	FN Test	100µg	EUR 658.5
Description: Antibody raised against CD163/M130

Mouse Monoclonal anti-Human CD163 Antibody
xAP-0134	Angio Proteomie	100ug	EUR 280

Mouse Monoclonal anti-Human CD163 Antibody
xAP-0135	Angio Proteomie	100ug	EUR 280

CD163 Rabbit anti-Human Polyclonal Antibody
MBS2402782-005mL	MyBiosource	0.05mL	EUR 615

CD163 Rabbit anti-Human Polyclonal Antibody
MBS2402782-5x005mL	MyBiosource	5x0.05mL	EUR 2605

CD163 Rabbit anti-Human Polyclonal Antibody
MBS2403148-005mg	MyBiosource	0.05mg	EUR 615

CD163 Rabbit anti-Human Polyclonal Antibody
MBS2403148-5x005mg	MyBiosource	5x0.05mg	EUR 2605

Anti-Hu CD163 PE
1P-645-T025	ExBio	25 tests	EUR 121

Anti-Hu CD163 PE
1P-645-T100	ExBio	100 tests	EUR 242

Anti-Hu CD163 PE
MBS1800644-100Tests	MyBiosource	100Tests	EUR 345

Anti-Hu CD163 PE
MBS1800644-5x100Tests	MyBiosource	5x100Tests	EUR 1300

Anti-Hu CD163 APC
1A-645-T025	ExBio	25 tests	EUR 121

Anti-Hu CD163 APC
1A-645-T100	ExBio	100 tests	EUR 242

Anti-Hu CD163 APC
MBS1800643-100Tests	MyBiosource	100Tests	EUR 345

Anti-Hu CD163 APC
MBS1800643-5x100Tests	MyBiosource	5x100Tests	EUR 1300

MOUSE ANTI RAT CD163
MBS216354-01mg	MyBiosource	0.1mg	EUR 455

MOUSE ANTI RAT CD163
MBS216354-5x01mg	MyBiosource	5x0.1mg	EUR 1885

MOUSE ANTI RAT CD163
MBS216356-025mg	MyBiosource	0.25mg	EUR 620

MOUSE ANTI RAT CD163
MBS216356-5x025mg	MyBiosource	5x0.25mg	EUR 2620

MOUSE ANTI PIG CD163
MBS224621-01mg	MyBiosource	0.1mg	EUR 420

MOUSE ANTI PIG CD163
MBS224621-5x01mg	MyBiosource	5x0.1mg	EUR 1715

Anti-Hu CD163 Purified
11-645-C025	ExBio	0.025 mg	EUR 71.5

Anti-Hu CD163 Purified
11-645-C100	ExBio	0.1 mg	EUR 143

Anti-Hu CD163 Purified
MBS1800642-01mg	MyBiosource	0.1mg	EUR 260

Anti-Hu CD163 Purified
MBS1800642-5x01mg	MyBiosource	5x0.1mg	EUR 930

Anti-Human CD163 (ABT-CD163) Mouse Monoclonal Antibody (Ready to Use)
MBS9511396-12mLRTU	MyBiosource	12mL(RTU)	EUR 530

Anti-Human CD163 (ABT-CD163) Mouse Monoclonal Antibody (Ready to Use)
MBS9511396-3mLRTU	MyBiosource	3mL(RTU)	EUR 240

Anti-Human CD163 (ABT-CD163) Mouse Monoclonal Antibody (Ready to Use)
MBS9511396-5x12mLRTU	MyBiosource	5x12mL(RTU)	EUR 2230

Anti-Human CD163 (ABT-CD163) Mouse Monoclonal Antibody (Ready to Use)
MBS9511396-6mLRTU	MyBiosource	6mL(RTU)	EUR 325

CD163 Antigen (CD163) Rabbit anti-Human Polyclonal (N-Terminus) (K20-T) Antibody
GWB-B1E200	GenWay Biotech	0.05 ml	Ask for price

Human CD163 Protein, His Tag
CD3-H52E8	ACROBIOSYSTEMS	1mg	EUR 374.5
Description: Human CD163, His Tag (CD3-H52E8) is expressed from human 293 cells (HEK293). It contains AA Ser 42 - Ser 1045 (Accession # Q86VB7).

Human CD163 PicoKine ELISA Kit
EK0715	BosterBio	96 wells	EUR 510
Description: For quantitative detection of human CD163 in cell culture supernates, serum and plasma(heparin).

Human CD163 knockout cell line
ABC-KH2671	AcceGen	1 vial	Ask for price
Description: Human CD163 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human CD163 PicoKine ELISA Kit
MBS176496-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 2755

Human CD163 PicoKine ELISA Kit
MBS176496-96StripWells	MyBiosource	96-Strip-Wells	EUR 600

Human CD163 knockdown cell line
ABC-KD2671	AcceGen	1 vial	Ask for price
Description: Human CD163 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human CD163 Protein Lysate 20ug
IHUCD163PLLY20UG	Innovative research	each	EUR 213
Description: Human CD163 Protein Lysate 20ug

Rabbit Polyclonal to Human CD163
MBS245302-0125mL	MyBiosource	0.125mL	EUR 620

Rabbit Polyclonal to Human CD163
MBS245302-5x0125mL	MyBiosource	5x0.125mL	EUR 2695

CD163, Human, mAb RM3/1
MBS584200-01mg	MyBiosource	0.1mg	EUR 710

CD163, Human, mAb RM3/1
MBS584200-05mg	MyBiosource	0.5mg	EUR 1695

CD163, Human, mAb RM3/1
MBS584200-1mg	MyBiosource	1mg	EUR 2370

CD163, Human, mAb RM3/1
MBS584200-5mg	MyBiosource	5mg	EUR 7845

Recombinant Human CD163, GST-tagged
CD163-10910H	Creative BioMart	25ug	EUR 255.2
Description: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.

PE Anti-human CD163 Antibody *GHI/61*
116301K0	AAT Bioquest	25 tests	EUR 391
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PE Anti-human CD163 Antibody *GHI/61*
116301K0-25tests	AAT Bioquest	25 tests	EUR 383
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PE Anti-human CD163 Antibody *GHI/61*
116301K1	AAT Bioquest	100 tests	EUR 1015
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PE Anti-human CD163 Antibody *GHI/61*
116301K1-100tests	AAT Bioquest	100 tests	EUR 995
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PE Anti-human CD163 Antibody *GHI/61*
116301K2	AAT Bioquest	500 tests	EUR 3044
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PE Anti-human CD163 Antibody *GHI/61*
116301K2-500tests	AAT Bioquest	500 tests	EUR 2984
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

APC Anti-human CD163 Antibody *GHI/61*
116301B0	AAT Bioquest	25 tests	EUR 391
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

APC Anti-human CD163 Antibody *GHI/61*
116301B0-25tests	AAT Bioquest	25 tests	EUR 383
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

APC Anti-human CD163 Antibody *GHI/61*
116301B1	AAT Bioquest	100 tests	EUR 1015
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

APC Anti-human CD163 Antibody *GHI/61*
116301B1-100tests	AAT Bioquest	100 tests	EUR 995
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

APC Anti-human CD163 Antibody *GHI/61*
116301B2	AAT Bioquest	500 tests	EUR 3044
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

APC Anti-human CD163 Antibody *GHI/61*
116301B2-500tests	AAT Bioquest	500 tests	EUR 2984
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

CD163 ORF Vector (Human) (pORF)
ORF017045	ABM	1.0 ug DNA	EUR 486

Alexa Fluor® 647 anti-human CD163
E16FHK163-025	EnoGene	25 tests	EUR 433.33
Description: Available in various conjugation types.

Alexa Fluor® 647 anti-human CD163
E16FHK163-100	EnoGene	100 tests	EUR 975
Description: Available in various conjugation types.

FITC Anti-human CD163 Antibody *GHI/61*
116301G0	AAT Bioquest	100 tests	EUR 558
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

FITC Anti-human CD163 Antibody *GHI/61*
116301G0-100tests	AAT Bioquest	100 tests	EUR 547
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

FITC Anti-human CD163 Antibody *GHI/61*
116301G1	AAT Bioquest	500 tests	EUR 2093
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

FITC Anti-human CD163 Antibody *GHI/61*
116301G1-500tests	AAT Bioquest	500 tests	EUR 2051
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

CD163 (Human) LumiAb ELISA Kit
MBS9510961-1x96Wells	MyBiosource	1x96Wells	EUR 520

CD163 (Human) LumiAb ELISA Kit
MBS9510961-5x96Wells	MyBiosource	5x96Wells	EUR 2395

TRITC Anti-human CD163 Antibody *GHI/61*
116301H0	AAT Bioquest	100 tests	EUR 558
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

TRITC Anti-human CD163 Antibody *GHI/61*
116301H0-100tests	AAT Bioquest	100 tests	EUR 547
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

TRITC Anti-human CD163 Antibody *GHI/61*
116301H1	AAT Bioquest	500 tests	EUR 2093
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

TRITC Anti-human CD163 Antibody *GHI/61*
116301H1-500tests	AAT Bioquest	500 tests	EUR 2051
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PerCP Anti-human CD163 Antibody *GHI/61*
116301S0	AAT Bioquest	25 tests	EUR 391
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PerCP Anti-human CD163 Antibody *GHI/61*
116301S0-25tests	AAT Bioquest	25 tests	EUR 383
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PerCP Anti-human CD163 Antibody *GHI/61*
116301S1	AAT Bioquest	100 tests	EUR 1015
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PerCP Anti-human CD163 Antibody *GHI/61*
116301S1-100tests	AAT Bioquest	100 tests	EUR 995
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PerCP Anti-human CD163 Antibody *GHI/61*
116301S2	AAT Bioquest	500 tests	EUR 3044
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PerCP Anti-human CD163 Antibody *GHI/61*
116301S2-500tests	AAT Bioquest	500 tests	EUR 2984
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PacBlue Anti-human CD163 Antibody *GHI/61*
116301I0	AAT Bioquest	100 tests	EUR 558
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PacBlue Anti-human CD163 Antibody *GHI/61*
116301I0-100tests	AAT Bioquest	100 tests	EUR 547
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PacBlue Anti-human CD163 Antibody *GHI/61*
116301I1	AAT Bioquest	500 tests	EUR 2093
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PacBlue Anti-human CD163 Antibody *GHI/61*
116301I1-500tests	AAT Bioquest	500 tests	EUR 2051
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

CD163 (Human) Sandwich ELISA Kit
OK-0312	Assay Biotech	1Kit	EUR 280
Description: CD163 (Human) Colorimetric Sandwich ELISA Kit

CD163 (Human) OmniKine ELISA Kit
MBS9502033-1x96Wells	MyBiosource	1x96Wells	EUR 500

CD163 (Human) OmniKine ELISA Kit
MBS9502033-5x96Wells	MyBiosource	5x96Wells	EUR 2300

Purified Anti-human CD163 Antibody *GHI/61*
11630000	AAT Bioquest	100 ug	EUR 373
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

Purified Anti-human CD163 Antibody *GHI/61*
11630000-100ug	AAT Bioquest	100 ug	EUR 365
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PacOrange Anti-human CD163 Antibody *GHI/61*
116301J0	AAT Bioquest	100 tests	EUR 558
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PacOrange Anti-human CD163 Antibody *GHI/61*
116301J0-100tests	AAT Bioquest	100 tests	EUR 547
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PacOrange Anti-human CD163 Antibody *GHI/61*
116301J1	AAT Bioquest	500 tests	EUR 2093
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PacOrange Anti-human CD163 Antibody *GHI/61*
116301J1-500tests	AAT Bioquest	500 tests	EUR 2051
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

CD163 ELISA Kit (Human) (OKCD07621)
OKCD07621	Aviva Systems Biology	96 Wells	EUR 1123.2
Description: Description of target: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.273ng/mL

CD163 ELISA Kit (Human) (OKAN04666)
OKAN04666	Aviva Systems Biology	96 Wells	EUR 950.4
Description: Description of target: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.273 ng/mL

CD163 ELISA Kit (Human) (OKBB00786)
OKBB00786	Aviva Systems Biology	96 Wells	EUR 606
Description: Description of target: CD163(Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. It has also been shown to mark cells of monocyte/macrophage lineage. CD163, a member of the scavenger receptor cysteine-rich(SRCR) superfamily, is exclusively expressed by monocytes and macrophages. Using FISH, somatic cell hybrid analysis, and radiation hybrid analysis, CD163 gene was mapped the to chromosome 12p13.3. CD163 is upregulated in a large range of diseases inflammatory diseases including type 2 diabetes, macrophage activation sickness, Tangier's disease, reumatoid arthritis etc.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <150pg/ml

CD163 ELISA Kit (Human) (OKBB01513)
OKBB01513	Aviva Systems Biology	96 Wells	EUR 684
Description: Description of target: CD163(Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. It has also been shown to mark cells of monocyte/macrophage lineage. CD163, a member of the scavenger receptor cysteine-rich(SRCR) superfamily, is exclusively expressed by monocytes and macrophages. Using FISH, somatic cell hybrid analysis, and radiation hybrid analysis, CD163 gene was mapped the to chromosome 12p13.3. CD163 is upregulated in a large range of diseases inflammatory diseases including type 2 diabetes, macrophage activation sickness, Tangier's disease, reumatoid arthritis etc.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <150pg/ml

Impact of Serotype and Pressure Variety on Dengue Virus Replication in Australian Mosquito Vectors

Dengue virus (DENV) is crucial mosquito-borne viral pathogen of people, comprising 4 serotypes (DENV-1 to -4) with a myriad of genotypes and strains. The kinetics of DENV replication inside the mosquito following ingestion of a blood meal affect the pathogen’s potential to achieve the salivary glands and thus the transmission potential. The affect of DENV serotype and pressure variety on virus kinetics within the two essential vector species, Aedes aegypti and Ae. albopictus, has been poorly characterised. We examined whether or not DENV replication kinetics differ systematically amongst serotypes and strains, utilizing Australian strains of the 2 vectors.

Mosquitoes have been blood fed with two strains per serotype, and sampled at 3, 6, 10 and 14-days post-exposure. Virus an infection in mosquito our bodies, and dissemination of virus to legs and wings, was detected utilizing qRT-PCR. For each vectors, we discovered important variations amongst serotypes in proportions of mosquitoes contaminated, with greater numbers for DENV-1 and -2 versus different serotypes. In line with this, we noticed that DENV-1 and -2 usually replicated to greater RNA ranges than different serotypes, significantly at earlier time factors.

There have been no important variations in both pace of an infection or dissemination between the mosquito species. Our outcomes recommend that DENV variety might have essential epidemiological penalties by influencing virus kinetics in mosquito vectors.

A Plant Virus Ensures Viral Stability within the Hemolymph of Vector Bugs via Suppressing Prophenoloxidase Activation

Most plant viruses require vector bugs for transmission. Viral stability within the hemolymph of vector bugs is a prerequisite for profitable transmission of persistent plant viruses. Nevertheless, data of whether or not the proteolytic activation of prophenoloxidase (PPO) impacts the soundness of persistent plant viruses stays elusive.

Right here, we explored the interaction between rice stripe virus (RSV) and the PPO cascade of the vector small brown planthopper. Phenoloxidase (PO) exercise was suppressed by RSV by roughly 60%.

When the PPO cascade was activated, we discovered distinct melanization round RSV particles and critical harm to viral stability within the hemolymph. Viral suppression of PO exercise was derived from obstruction of proteolytic cleavage of PPOs by binding of the viral nonstructural protein NS3.

These outcomes point out that RSV attenuates the PPO response to make sure viral stability within the hemolymph of vector bugs. Our analysis gives enlightening cues for controlling the transmission of vector-borne viruses.

IMPORTANCE Massive ratios of vector-borne plant viruses flow into within the hemolymph of their vector bugs earlier than getting into the salivary glands to be transmitted to crops.

The soundness of virions within the hemolymph is significant on this course of. Activation of the proteolytic prophenoloxidase (PPO) to supply lively phenoloxidase (PO) is likely one of the main innate immune pathways in insect hemolymph.

How a plant virus copes with the PPO immune response in its vector insect stays unclear. Right here, we report that the PPO impacts the soundness of rice stripe virus (RSV), a infamous rice virus, within the hemolymph of a vector insect, the small brown planthopper. RSV suppresses PPO activation utilizing viral nonstructural protein.

As soon as the extent of PO exercise is elevated, RSV is melanized and eradicated from the hemolymph. Our work offers precious clues for creating novel methods for controlling the transmission of vector-borne plant viruses.

Nori® Human CCL-15/MIP-5 ELISA Kit
GR111519	Genorise Scientific	96-well	EUR 461

Human CCL-14
hAP-0138	Angio Proteomie	100ug	EUR 250

Human CCL-14
hAP-0138A	Angio Proteomie	100ug	EUR 250

Anti-Human CCL-11 Antibody
101-M161	ReliaTech	100 µg	EUR 399
Description: CCL11 is a potent eosinophil chemoattractant that was originally purified from bronchoalveolar lavage fluid of guinea pigs sensitized by aerosol challenge with ovalbumin. Microsequencing of the purified protein revealed the guinea pig CCL11 to be a member of the beta (CC) chemokine family of inflammatory and immunoregulatory cytokines. cDNA clones for guinea pig, mouse, and human CCL11 have been isolated. Human CCL11 cDNA encodes a 97 amino acid residue precursor protein from which the aminoterminal 23 amino acid residues are cleaved to generate the 74 amino acid residue mature human CCL11. At the protein sequence level, mature human CCL11 is approximately 60% identical to mature mouse and guinea pig CCL11. In addition, human CCL11 also shows high amino acid sequence identity to human MCP1, 2, and 3. Human CCL11 is chemotactic for eosinophils, but not mononuclear cells or neutrophils. The CC chemokine receptor 3 (CCR3) has now been identified to be a specific human CCL11 receptor. CCR3 has also been shown to serve as a cofactor for a restricted subset of primary HIV viruses and binding of CCL11 to CCR3 inhibited infection by the HIV isolates.

Anti-Human CCL-14 Antibody
101-M162	ReliaTech	100 µg	EUR 399
Description: CCL14 is a chemokine that promotes chemotaxis of T cells, monocytes, and eosinophils. It occurs in two isoforms resulting from differential mRNA splicing. Following cleavage of a 19 amino acid signal peptide, mature CCL14a (aa 20-93) is a 74 amino acid peptide that is also known as HCC1 (Hemofiltrate CC Chemokine1). It is a weak CCR1 agonist, however, an 8 amino acid Nterminal truncation (aa 28 93) allows potent signaling through CCR1 and CCR5. CCL14b, also called HCC3, is a 90 amino acid peptide (aa 20-109) resulting from the insertion of 16 amino acids between residues 7 and 8 of CCL14a.

Anti-Human CCL-28 Antibody
101-M185	ReliaTech	100 µg	EUR 399
Description: CCL-28 or MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting CD4, CD8 T-cells and eosinophils. MEC contains six cysteines including the four highly conserved cysteine residues present in CC chemokines. Recombinant human MEC is a 12.3 kDa protein containing 108 amino acid residues.

Anti-Human CCL-14 Antibody
101-M246	ReliaTech	100 µg	EUR 399
Description: CCL14 is a chemokine that promotes chemotaxis of T cells, monocytes, and eosinophils. It occurs in two isoforms resulting from differential mRNA splicing. Following cleavage of a 19 amino acid signal peptide, mature CCL14a (aa 20-93) is a 74 amino acid peptide that is also known as HCC1 (Hemofiltrate CC Chemokine1). It is a weak CCR1 agonist, however, an 8 amino acid Nterminal truncation (aa 28 93) allows potent signaling through CCR1 and CCR5. CCL14b, also called HCC3, is a 90 amino acid peptide (aa 20-109) resulting from the insertion of 16 amino acids between residues 7 and 8 of CCL14a.

Anti-Human CCL-11 Antibody
101-M256	ReliaTech	100 µg	EUR 399
Description: CCL11 is a potent eosinophil chemoattractant that was originally purified from bronchoalveolar lavage fluid of guinea pigs sensitized by aerosol challenge with ovalbumin. Microsequencing of the purified protein revealed the guinea pig CCL11 to be a member of the beta (CC) chemokine family of inflammatory and immunoregulatory cytokines. cDNA clones for guinea pig, mouse, and human CCL11 have been isolated. Human CCL11 cDNA encodes a 97 amino acid residue precursor protein from which the aminoterminal 23 amino acid residues are cleaved to generate the 74 amino acid residue mature human CCL11. At the protein sequence level, mature human CCL11 is approximately 60% identical to mature mouse and guinea pig CCL11. In addition, human CCL11 also shows high amino acid sequence identity to human MCP1, 2, and 3. Human CCL11 is chemotactic for eosinophils, but not mononuclear cells or neutrophils. The CC chemokine receptor 3 (CCR3) has now been identified to be a specific human CCL11 receptor. CCR3 has also been shown to serve as a cofactor for a restricted subset of primary HIV viruses and binding of CCL11 to CCR3 inhibited infection by the HIV isolates.

Anti-Human CCL-13 Antibody
101-M257	ReliaTech	100 µg	EUR 399
Description: CCL13, also known as Monocyte Chemoattractant Protein4 (MCP4), is a CC chemokine that acts as a chemoattractant for monocytes, eosinophils and T cells and as an activator of basophils. Human CCL13 cDNA encodes a 98 amino acid residue precursor protein with a 23 amino acid residue hydrophobic signal peptide that is cleaved to yield an 8 kDa, 75 aa mature CCL13. Mature CCL13 lacks any potential N-glycosylation sites and shares a pyroglutamate proline motif with other human MCP proteins. Human CCL13 is most homologous to MCP1, 3 and Eotaxin, exhibiting approximately 65-66% amino acid sequence identity. CCL13 mRNA is expressed by a number of activated cell types, including endothelial cells, macrophages, bronchial epithelium and type II alveolar cells, and perhaps lymphocytes. The bioactivities of CCL13 are mediated by the CC chemokine receptors CCR2 and CCR3.

Anti-Human CCL-16 Antibody
101-M259	ReliaTech	100 µg	EUR 399
Description: CCL16, also known as HCC-4, is a CC chemokine that interacts with CCR1, CCR2, and CCR5. CCL16 is expressed weakly by NK cells, γδ T cells, and some T cells and is upregulated in monocytes by IL-10. CCL16 functions as a chemoattractant for monocytes and promotes the maturation of monocyte derived dendritic cells.

Anti-Human CCL-17 Antibody
101-M260	ReliaTech	100 µg	EUR 399
Description: CCL17 is a novel CC chemokine identified using a signal sequence trap method. CCL17 cDNA encodes a highly basic 94 amino acid (aa)residue precursor protein with a 23 aa residue signal peptide that is cleaved to generate the 71 aa residue mature secreted protein. Among CC chemokine family members, CCL17 has approximately 24-29% amino acid sequence identity with RANTES, MIP1α, MIP1β, MCP1, MCP2, MCP3, and I309. The gene for human CCL17 has been mapped to chromosome 16q13 rather than chromosome 17 where the genes for many human CC chemokines are clustered. CCL17 is constitutively expressed in thymus, and at a lower level in lung, colon, and small intestine. CCL17 is also transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant CCL17 has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL17 was identified to be a specific functional ligand for CCR4, a receptor that is selectively expressed on T cells.

Anti-Human CCL-18 Antibody
101-M261	ReliaTech	100 µg	EUR 399
Description: CCL18, also known as PARC (Pulmonary and Activation-regulated Chemokine), is expressed by monocyte-derived dendritic cells and Th2 cytokine-stimulated macrophages. It functions as a chemoattractant for naïve T cells but not monocytes or neutrophils.

Anti-Human CCL-19 Antibody
101-M262	ReliaTech	100 µg	EUR 399
Description: CCL19, also known as MIP3β and ELC (EBI1Ligand Chemokine), is a 77 amino acid (aa) β chemokine that is distantly related to other β chemokines (20-30% aa sequence identity). The gene for MIP3β has been mapped to chromosome 9p13 rather than chromosome 17 where the genes for many human β chemokines are clustered. MIP3β is constitutively expressed in various lymphoid tissues (including thymus, lymph nodes, appendix and spleen). The expression of MIP3β is downregulated by the antiinflammatory cytokine IL10. Recombinant MIP3β is chemotactic for cultured human lymphocytes. MIP3β is a ligand for CCR7 (previously referred to as the EpsteinBarr virus-induced gene 1 (EBI1) orphan receptor), a chemokine receptor that is expressed in various lymphoid tissues and activated B and T lymphocytes. CCR7 is strongly upregulated in B cells infected with EpsteinBarr virus and T cells infected with herpesvirus 6 or 7.

Anti-Human CCL-20 Antibody
101-M264	ReliaTech	100 µg	EUR 399
Description: CCL20, also known as LARC (Liver and Activation-regulated Chemokine) and as Exodus, is one of many novel β chemokines identified through bioinformatics. CCL20 cDNA encodes a 96 amino acid (aa) residue precursor protein with a 26 aa residue signal peptide that is predicted to be cleaved to form the 70 aa residue mature secreted protein. CCL20 is distantly related to other β chemokines (20-28% aa sequence identity) and the gene for CCL20 has been mapped to chromosome 2 rather than 17. CCL20 has been shown to be expressed predominantly in lymph nodes, appendix, PBL, fetal liver, fetal lung and several cell lines. The expression of CCL20 is strongly upregulated by inflammatory signals and downregulated by the anti-inflammatory cytokine IL10. Synthetic or recombinant CCL20 has been shown to be chemotactic for lymphocytes and to inhibit proliferation of myeloid progenitors in colony formation assays. CCL20 has now been shown to be a unique functional ligand for CCR6 (previously referred to as GPRCY4, CKRL3, or STRL22 orphan receptor), a chemokine receptor that is selectively and highly expressed in human dendritic cells derived from CD34+ cord blood precursors.

Anti-Human CCL-21 Antibody
101-M265	ReliaTech	100 µg	EUR 399
Description: 6Ckine or CCL-21 is a novel CC chemokine discovered independently by three groups from the EST database. 6Ckine, also named SLC (Secondary Lymphoid-tissue Chemokine), CCL21 and Exodus2, shows 21 33% identity to other CC chemokines. 6Ckine contains the four conserved cysteines characteristic of β chemokines plus two additional cysteines in its unusually long carboxy-lterminal domain. Human 6Ckine cDNA encodes a 134 amino acid residue, highly basic, precursor protein with a 23 amino acid residue signal peptide that is cleaved to form the predicted 111 amino acid residue mature protein. Mouse 6Ckine cDNA encodes a 133 amino acid residue protein with a 23 residue signal peptide that is cleaved to generate the 110 residue mature protein. Human and mouse 6Ckine are highly conserved, exhibiting 86% amino acid sequence identity. 6Ckine is constitutively expressed at high levels in lymphoid tissues such as lymph nodes, spleen and appendix. In mouse, high levels of 6Ckine mRNA are also detected in the lung. The gene for human 6Ckine has been localized at human chromosome 9p13 rather than chromosome 17 where the genes of many human CC chemokines are clustered. The 6Ckine gene location is within a region of about 100 kb from the gene for MIP3β/ ELC, another novel CC chemokine.

Anti-Human CCL-22 Antibody
101-M266	ReliaTech	100 µg	EUR 399
Description: CCL22, also named stimulated T cell chemotactic protein (STCP1) and MDC, is a CC chemokine initially isolated from clones of monocytederived macrophages. Human CCL22 cDNA encodes a precursor protein of 93 amino acid residues with a 24 amino acid residue predicted signal peptide that is cleaved to yield a 69 amino acid residue mature 8 kDa protein. At the amino acid sequence level, CCL22 shows less than 35% identity to other CC chemokine family members. Human CCL22 is expressed in dendritic cells, macrophages and activated monocytes. In addition, CCL22 expression is also detected in the tissues of thymus, lymph node and appendix. The gene for human CCL22 has been mapped to chromosome 16 rather than chromosome 17 where the genes for many human CC chemokines are clustered. Recombinant or chemically synthesized mature CCL22 has been shown to induce chemotaxis or Ca2+ mobilization in dendritic cells, IL2 activated NK cells, and activated T lymphocytes. A CD8+ T lymphocytederived secreted soluble activity that suppresses infection by primary non-syncytium-inducing and syncytium-inducing HIV1 isolates and the T cell lineadapted isolate HIV1 IIIB, has been identified as CCL22. Based on aminoterminal sequence analysis, the major CD8 + T lymphocyte-derived CCL22 protein yielded an amino-terminal sequence of YGANM, which is two amino acid residues shorter than the predicted mature CCL22. The difference in potency between the two mature CCL22 isoforms has not been determined.

Anti-Human CCL-23 Antibody
101-M267	ReliaTech	100 µg	EUR 399
Description: CCL23, also known as Myeloid Progenitor Inhibitory Factor1 (MPIF1), is a CC chemokine that is produced by some myeloid cell lines and monocytederived dendritic cells. It binds CCR1 and inhibits the differentiation of progenitor cells that give rise to granulocytes and macrophages. CCL23 is also chemotactic for resting T cells, neutrophils, monocytes and dendritic cells.

Anti-Human CCL-24 Antibody
101-M268	ReliaTech	100 µg	EUR 399
Description: Eotaxin2, also named MPIF2 and Ckβ6, is a CC chemokine that is designated CCL24. Eotaxin2 cDNA encodes a 10.5 kDa, 119 amino acid residue precursor protein with a 26 aa residue signal peptide that is cleaved to generate a mature protein predicted to contain 93 amino acid residues with an N-glycosylation site. C-terminally truncated variants with 78, 73, 75 and 76 residues have also been described. Eotaxin 2 shares 40%, 42% and 39% amino acid sequence identity with other CC chemokines CCL7/MCP3, CCL3/MIP1α, and CCL11/Eotaxin, respectively. Eotaxin2 mRNA is weakly expressed in activated monocytes and T lymphocytes. Recombinant Eotaxin2 induces chemotaxis of eosinophils, basophils, and resting T lymphocytes, but not monocytes or activated T lymphocytes. Eotaxin2 also suppresses colony formation by high proliferative multipotential hematopoietic progenitors. On eosinophils, the effects of Eotaxin2, Eotaxin and CCL13/MCP4 are mediated by the receptor CCR3.

Anti-Human CCL-25 Antibody
101-M269	ReliaTech	100 µg	EUR 399
Description: CCL25 (thymus-expressed chemokine) is a CC chemokine that is distantly related (approximately 20% amino acid sequence identity) to other CC chemokines. Human CCL25 cDNA encodes a 150 aa precursor protein with a 23 aa signal peptide that is cleaved to yield a 127 aa mature protein. Mouse CCL25 cDNA has also been cloned and shown to encode a 144 aa protein that exhibits 49% aa sequence identity to human CCL25. The expresssion of human and mouse CCL25 was shown to be highly restricted to the thymus and small intestine. Although dendritic cells have been demonstrated to be the source of CCL25 production in the thymus, dendritic cells derived from bone marrow do not express CCL25. The gene for mouse CCL25 has been mapped to chromosome 8 rather than chromosome 11 where many mouse CC chemokines are clustered. Recombinant human and mouse CCL25 are chemotactic for activated macrophages, dendritic cells and thymocytes. CCL25 is also a specific agonist for the CCR9 chemokine receptor.

Anti-Human CCL-26 Antibody
101-M270	ReliaTech	100 µg	EUR 399
Description: Eotaxin-3 is a CC chemokine that signals through the CCR3 receptor. It is produced by endothelial cells stimulated with IL-4 or IL-13. Eotaxin-3 selectively targets cells expressing CCR3, including eosinophils, basophils, T cells and monocytes. Eotaxin-3 has similar activity to Eotaxin and Eotaxin-2, but the three Eotaxins share only a low degree of sequence homology. Recombinant human Eotaxin-3 is an 8.4 kDa protein containing 71 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Anti-Human CCL-27 Antibody
101-M271	ReliaTech	100 µg	EUR 399
Description: CTACK or CCL-27 is a keratinocyte-derived CC chemokine which signals through the CCR10 receptor. Both CTACK and CCR10 are expressed in normal and irritated epithelial cells. CTACK selectively attracts CLA+ T-cells and directs them into the skin. CTACK contains the four highly conserved cysteine residues present in most CC chemokines. The mature protein contains 88 amino acid residues. Recombinant human CTACK is a 10.2 kDa protein containing 88 amino acid residues.

Anti-Human CCL-28 Antibody
101-M272	ReliaTech	100 µg	EUR 399
Description: CCL-28 or MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting CD4, CD8 T-cells and eosinophils. MEC contains six cysteines including the four highly conserved cysteine residues present in CC chemokines. Recombinant human MEC is a 12.3 kDa protein containing 108 amino acid residues.

Anti-Human CCL-1 Antibody
101-M255	ReliaTech	100 µg	EUR 399
Description: ccbe1 is not expressed in endothelial cells of lymph vessels, and it may be a component of the extracellular matrix. In zebrafish, ccbe1 expression was observed along the earliest migra­tion routes of endothelial cells that sprout from the posterior cardinal vein and migrate circuitously before developing into lymphatic vessels. ccbe1 might therefore be involved in guidance of these migrating cells.

Anti-Human CCL-2 Antibody
101-M263	ReliaTech	100 µg	EUR 399
Description: CCL2 is a βchemokine that is also known as monocyte chemotactic protein 1 (MCP1). It is produced by a variety of cell types and is chemotactic for monocytes.

Anti-Human CCL-3 Antibody
101-M273	ReliaTech	100 µg	EUR 399
Description: The macrophage inflammatory proteins 1α and 1β were originally copurified from medium conditioned by an LPS-stimulated murine macrophage cell line. Human MIP1α refers to the products of several independently cloned cDNAs, including LD78, pL78, pAT464, and GOS19. These cDNAs all code for the same human protein that is a homologue of the murine MIP 1α. Mature MIP1α and MIP1β in both human and mouse share approximately 70% homology at the amino acid level. The MIP1 proteins are members of the β (CC) subfamily of chemokines. Both MIP1α and MIP1β are monocyte chemoattractants in vitro. Additionally, the MIP1 proteins have been reported to have chemoattractant and adhesive effects on lymphocytes, with MIP1α and MIP1β preferentially attracting CD8+ and CD4+ T cells, respectively. MIP1α has also been shown to attract B cells as well as eosinophils. MIP1 proteins have been reported to have multiple effects on hematopoietic precursor cells and MIP1α has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. The functional receptor for MIP1α has been identified as CCR1 and CCR5.

Anti-Human CCL-5 Antibody
101-M274	ReliaTech	100 µg	EUR 399
Description: CCL5, also known as RANTES (Regulated upon Activation, Normal T cell Expressed and presumably Secreted) is a member of the β (CC) chemokine subfamily. It binds and activates the chemokine receptors CCR1, 3 and 5.

Anti-Human CCL-7 Antibody
101-M275	ReliaTech	100 µg	EUR 399
Description: MCP2 and CCL7 are two monocyte chemotactic proteins produced by human MG63 osteosarcoma cells. Both MCP2 and CCL7 are members of the CC family of chemokines and share 62% and 71% amino acid sequence identity, respectively, with MCP1. CCL7 also shares 58% amino acid identity with MCP2. CCL7 cDNA encodes a 99 amino acid residue precursor protein from which the N-terminal 23 amino acid residues are cleaved to generate the 76 amino acid residue mature CCL7. Mature CCL7 contains a potential N-linked and several possible O-linked glycosylation sites. Similarly to other CC chemokines, all three MCP proteins are monocyte chemoattractants. In addition, the three MCPs can chemoattract activated NK cells as well as CD4+ and CD8+ T lymphocytes. All three cytokines have also been shown to attract eosinophils and induce histamine secretion from basophils.

Anti-Human CCL-8 Antibody
101-M276	ReliaTech	100 µg	EUR 399
Description: CCL8, also known as Monocyte Chemoattractant Protein 2 (MCP2), is an inflammatory CC chemokine that attracts monocytes, eosinophils and basophils. It is produced by many cell types and signals through interactions with CCR1, CCR2, CCR3 and CCR5.

Anti-Human CCL-17 (TARC) Antibody
101-M164	ReliaTech	100 µg	EUR 399
Description: CCL17 is a novel CC chemokine identified using a signal sequence trap method. CCL17 cDNA encodes a highly basic 94 amino acid (aa)residue precursor protein with a 23 aa residue signal peptide that is cleaved to generate the 71 aa residue mature secreted protein. Among CC chemokine family members, CCL17 has approximately 24-29% amino acid sequence identity with RANTES, MIP1α, MIP1β, MCP1, MCP2, MCP3, and I309. The gene for human CCL17 has been mapped to chromosome 16q13 rather than chromosome 17 where the genes for many human CC chemokines are clustered. CCL17 is constitutively expressed in thymus, and at a lower level in lung, colon, and small intestine. CCL17 is also transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant CCL17 has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL17 was identified to be a specific functional ligand for CCR4, a receptor that is selectively expressed on T cells.

Anti-Human CCL-27 (CTACK) Antibody
101-M184	ReliaTech	100 µg	EUR 399
Description: CTACK or CCL-27 is a keratinocyte-derived CC chemokine which signals through the CCR10 receptor. Both CTACK and CCR10 are expressed in normal and irritated epithelial cells. CTACK selectively attracts CLA+ T-cells and directs them into the skin. CTACK contains the four highly conserved cysteine residues present in most CC chemokines. The mature protein contains 88 amino acid residues. Recombinant human CTACK is a 10.2 kDa protein containing 88 amino acid residues.

Mouse Monoclonal anti-Human CCL-11
hAP-0136	Angio Proteomie	100ug	EUR 250

Mouse Monoclonal anti-Human CCL-11
hAP-0136A	Angio Proteomie	100ug	EUR 250

Mouse Monoclonal anti-human CCL-28
hAP-0153	Angio Proteomie	100ug	EUR 250

Mouse Monoclonal anti-human CCL-28
hAP-0153A	Angio Proteomie	100ug	EUR 250

Sheep Polyclonal anti-Human CCL-28
hAP-5717	Angio Proteomie	50ug	EUR 400

Anti-Human CCL-5 (RANTES) Antibody
101-M191	ReliaTech	100 µg	EUR 399
Description: CCL5, also known as RANTES (Regulated upon Activation, Normal T cell Expressed and presumably Secreted) is a member of the β (CC) chemokine subfamily. It binds and activates the chemokine receptors CCR1, 3 and 5.

Human RANTES (CCL 5)
MBS692044-0005mg	MyBiosource	0.005mg	EUR 300

Human RANTES (CCL 5)
MBS692044-002mg	MyBiosource	0.02mg	EUR 450

Human RANTES (CCL 5)
MBS692044-5x002mg	MyBiosource	5x0.02mg	EUR 1725

Mouse Monoclonal anti-Human CCL-1
hAP-0135	Angio Proteomie	100ug	EUR 250

Human CCL-5 ELISA Kit
EHC0240	Abclonal	96Tests	EUR 625.2

Anti-Mouse CCL-11 Antibody
103-M321	ReliaTech	100 µg	EUR 399
Description: CCL11 is a potent eosinophil chemoattractant that was originally purified from bronchoalveolar lavage fluid of guinea pigs sensitized by aerosol challenge with ovalbumin. Mouse CCL11 cDNA encodes a 97 amino acid (aa) precursor protein from which the aminoterminal 23 aa are cleaved to generate the 74 aa mature mouse CCL11. At the protein sequence level, mature mouse CCL11 is approximately 60% identical to mature human and guinea pig CCL11. In addition, mouse CCL11 also shows high aa sequence identity to members of the MCP family. Mouse CCL11 is chemotactic for eosinophils, but not mononuclear cells or neutrophils. CCL11 mRNA is expressed in a variety of tissues. The expression of CCL11 mRNA is induced in cultured endothelial cells in response to IFNγ. In addition, CCL11 mRNA is also induced in response to the transplantation of IL4secreting tumor cells. The CC chemokine receptor 3 (CCR3) has been identified as a specific human CCL11 receptor.

Anti-Mouse CCL-12 Antibody
103-M322	ReliaTech	100 µg	EUR 399
Description: CCL12 is a cloned mouse CC chemokine most closely related to human MCP1 (66% amino acid (aa) sequence identity in the mature protein). Mouse CCL12 encodes a 104 aa residue precursor protein with a 22 aa residue predicted hydrophobic signal sequence that is cleaved to generate a 82 aa residue mature protein. CCL12 is expressed constitutively in the thymus and lymph nodes. Under inflammatory conditions, CCL12 expression is also induced in activated macrophages and mast cells. The gene for mouse MCP1 has been mapped to the CC chemokine cluster on chromosome 11. Recombinant CCL12 has been shown to be a potent chemoattractant for monocytes and lymphocytes but not neutrophils. At high concentrations, CCL12 will also chemoattract eosinophils. CCL12 has been found to be a functional ligand for CCR2 but not CCR1, CCR3, or CCR5.

Anti-Mouse CCL-17 Antibody
103-M323	ReliaTech	100 µg	EUR 399
Description: Human thymus and activationregulated chemokine (TARC) also known as CCL17, is a novel CC chemokine identified using a signal sequence trap method. Mouse CCL17 was discovered as a dendritic cell (DC) specific gene by differentiation RNA display. Mouse CCL17 cDNA encodes a highly basic 93 amino acid (aa) residue precursor protein with a 23 aa residue putative signal peptide that is cleaved to generate the 70 aa residue mature secreted protein. Among CC chemokine family members, CCL17 has approximately 24-29% amino acid sequence identity with RANTES, MIP1α, MIP1β, MCP1, MCP2, MCP3, and I309. The gene for human CCL17 has been mapped to chromosome 16q13 rather than chromosome 17 where the genes for many human CC chemokines are clustered. Mouse CCL17 is constitutively expressed in thymic DC, and at a lower level in lymph node DC in the lung. Recombinant CCL17 has been shown to be chemotactic for T cell lines and antigen-primed T helper cells. In humans, CCL17 was identified to be a specific functional ligand for CCR4 and CCR8, receptors that are selectively expressed on T cells.

Anti-Mouse CCL-19 Antibody
103-M324	ReliaTech	100 µg	EUR 399
Description: CCL19/MIP3β, also known as ELC (EBI1Ligand Chemokine), is a β chemokine that binds specifically to the chemokine receptor CCR7/EBI1/ BLR2. Mouse (human) CCL19 cDNA encodes a 108 (98) amino acid precursor protein with a predicted 25 (21) aa signal peptide that is cleaved to form the 83 (77) aa mature secreted protein. CCL19 is distantly related to other β chemokines (20-30% aa sequence identity). Mouse CCL19 shares 83% aa sequence homology with human CCL19. CCL19 has been shown to be constitutively expressed in various lymphoid tissues (including thymus, lymph nodes, appendix, and spleen) in dendritic cells within the T-cell zone. The expression of CCL19 is downregulated by the antiinflammatory cytokine IL10. Recombinant CCL19 has been shown to be chemotactic for Tcells and Bcells. The CCL19 receptor (CCR7/ EBI1/ BLR2) is expressed in various lymphoid tissues and activated B and T lymphocytes. CCR7 is also strongly upregulated in Bcells infected with EpsteinBarr virus and T-cells infected with herpesvirus 6 or 7.

Anti-Mouse CCL-20 Antibody
103-M326	ReliaTech	100 µg	EUR 399
Description: Macrophage inflammatory protein 3 alpha (MIP-3α) is a member of the CC chemokine superfamily and has been designated CCL20. CCL20 is a β chemokine that is strongly up-regulated by inflammatory signals and down-regulated by the anti-inflammatory cytokine IL-10. CCL20 binds to CCR6 to promote chemotaxis of lymphocytes and inhibit the proliferation of myeloid progenitors.

Anti-Mouse CCL-21 Antibody
103-M327	ReliaTech	100 µg	EUR 399
Description: 6Ckine is a novel CC chemokine discovered independently by three groups from the EST database. 6Ckine, also named SLC (secondary lymphoidtissue chemokine), CCL21 and Exodus2, shows 21-33% identity to other CC chemokines. 6Ckine contains the four conserved cysteines characteristic of β chemokines plus two additional cysteines in its unusually long carboxy-lterminal domain. Human 6Ckine cDNA encodes a 134 amino acid highly basic precursor protein with a 23 amino acid residue signal peptide that is cleaved to form the predicted 111 amino acid residue mature protein. Mouse 6Ckine cDNA encodes a 133 amino acid residue protein with a 23 residue signal peptide that is cleaved to generate the 110 residue mature protein. Human and mouse 6Ckine share 86% amino acid sequence identity. 6Ckine is constitutively expressed at high levels in lymphoid tissues such as lymph nodes, spleen and appendix. In mouse, high levels of 6Ckine mRNA are also detected in the lung. Unlike most CC chemokines, 6Ckine is not chemotactic for monocytes. Recombinant mouse 6Ckine is chemotactic in vitro for thymocytes and activated T cells. Recombinant human 6Ckine has been shown to be chemotactic for some human T cell lines, resting PBL, and cultured T cells expanded with PHA and IL2. 6Ckine has also been reported to inhibit hemopoietic progenitor colony formation in a dosedependent manner. 6Ckine acts via the CC receptor CCR7 on T cells and B cells.

Anti-Mouse CCL-22 Antibody
103-M328	ReliaTech	100 µg	EUR 399
Description: CCL22, also known as ABCD1 and MDC (macrophage-derived chemokine), is a CC chemokine cloned from activated mouse B cells. Mouse CCL22 cDNA encodes a precursor protein of 92 amino acid (aa) residues with a 24 aa residue predicted signal peptide that is cleaved to yield a 68 aa residue mature 7.8 kDa protein. At the amino acid sequence level, mouse and human CCL22 share 64% identity and 83% similarity. The genomic organization of the mouse and human CCL22 genes are very similar, exhibiting sequence identity at the intron-exon boundaries. Mouse CCL22 is expressed at high levels in dendritic cells and activated B lymphocytes. Low levels of mouse CCL22 mRNA are also detectable in lung, unstimulated spleen cells, lymph node cells and in thymocytes. CCL22 is a functional ligand for the CC chemokine receptor 4. Recombinant or chemically synthesized mature mouse CCL22 has been shown to induce chemotaxis or Ca2+ mobilization in activated mouse and human T cells.

Anti-Mouse CCL-24 Antibody
103-M329	ReliaTech	100 µg	EUR 399
Description: Eotaxin2, also named myeloid progenitor inhibitory factor (MPIF2), is a member of the CC chemokine subfamily and is designated CCL24. Eotaxin2 is constitutively expressed in the jejunum and spleen. It can also be induced in the lung by allergen challenge and IL4. LPS and IL4 also differentially regulate the expression of Eotaxin2 in monocytes and macrophages. Mouse Eotaxin2 cDNA encodes a 119 amino acid (aa) precursor protein that shares approximately 58% aa sequence identity with human Eotaxin2. Functionally, Eotaxin2is most closely related to CCL11/Eotaxin and CCL26/Eotaxin3. The three proteins share low sequence homology but have been shown to be potent eosinophil chemoattractants that bind and activate the chemokine receptor CCR3, a receptor that is highly expressed in eosinophils. Eotaxin2 also has the ability to suppress myeloid cell proliferation, a biological function not shared by Eotaxin.

Anti-Mouse CCL-25 Antibody
103-M330	ReliaTech	100 µg	EUR 399
Description: CCL25 (thymus expressed chemokine), also known as TECK (thymus-expressed chemokine), is a CC chemokine that is distantly related (twenty some % amino acid sequence identity) to other CC chemokines. Mouse CCL25 cDNA encodes a 144 amino acid residue precursor protein with a 23 amino acid residue signal peptide that is cleaved to yield a 121 residue mature protein. Mouse CCL25 shares 49% amino acid sequence identity with human CCL25. The expresssion of human and mouse CCL25 was shown to be highly restricted to the thymus and small intestine. Although dendritic cells have been demonstrated to be the source of CCL25 production in the thymus, dendritic cells derived from bone marrow do not express CCL25. The gene for mouse CCL25 has been mapped to chromosome 8.

Anti-Mouse CCL-27 Antibody
103-M331	ReliaTech	100 µg	EUR 399
Description: CCL27, also known as CTACK (cutaneous T cel-lattracting chemokine), ALP, ILC, and ESkine, is a member of the CC family of chemokines. Mature mouse CCL27 is a 95 amino acid (aa) protein that shares 57% aa and 87% aa sequence identity with human and rat CCL27, respectively. It shares 18-31% aa sequence identity with other mouse CC chemokines. An alternately spliced form of mouse CCL27, known as PESKY, is localized to the nucleus and promotes cellular migration. CCL27 is constitutively expressed by keratinocytes and is upregulated by inflammatory stimuli and in wounded skin. CCL27 binds the chemokine receptor CCR10, glycosaminoglycans in the extracellular matrix, sulfated tyrosine residues on PSGL1, and determinants on the surface of fibroblasts and endothelial cells. CCL27 cooperates with CCL17/TARC in inducing the migration of cutaneous lymphocyte antigen (CLA) positive memory T cells to the skin during inflammation. Endothelial cellbound CCL27 can mediate the adhesion of those cells to CLA+ T cells. CCL27 also induces the migration of keratinocyte precursors from bone marrow to the skin, thereby promoting wound healing. In humans, serum CCL27 levels are elevated and correlate with disease severity in atopic dermatitis, psoriasis vulgaris, and mycosis fungoides.

Anti-Mouse CCL-28 Antibody
103-M332	ReliaTech	100 µg	EUR 399
Description: Mouse CCL28 (CC chemokine ligand 28) is a novel CC chemokine cloned from a Rag1 mouse kidney cDNA library. Mouse CCL28 cDNA encodes a 130 amino acid (aa) precursor protein with a 22 aa signal peptide and a 108 aa mature protein. Mature human and mouse CCL28 share 83% aa identity. Among CC chemokines, CCL28 shares the most homology with CCL27/CTACK. Mouse CCL28 is produced by epithelial cells. Based on Northern blot analysis, it is mainly expressed in testes, kidney and brain. The receptor for CCL28 has been identified as the CCR10, which is also the receptor for CCL27/CTACK.

Anti-Human CCL-23 (MPIF-1) Antibody
101-M183	ReliaTech	100 µg	EUR 399
Description: CCL23, also known as Myeloid Progenitor Inhibitory Factor1 (MPIF1), is a CC chemokine that is produced by some myeloid cell lines and monocytederived dendritic cells. It binds CCR1 and inhibits the differentiation of progenitor cells that give rise to granulocytes and macrophages. CCL23 is also chemotactic for resting T cells, neutrophils, monocytes and dendritic cells.

Mouse Monoclonal anti-human CCL-22 (MDC)
hAP-0147	Angio Proteomie	100ug	EUR 250

Mouse Monoclonal anti-human CCL-17 (TARC)
hAP-0141	Angio Proteomie	100ug	EUR 250

Mouse Monoclonal anti-human CCL-17 (TARC)
hAP-0141A	Angio Proteomie	100ug	EUR 250

Mouse Monoclonal anti-human CCL-18 (PARC)
hAP-0142	Angio Proteomie	100ug	EUR 250

Mouse Monoclonal anti-human CCL-25 (TECK)
hAP-0150	Angio Proteomie	100ug	EUR 250

Sheep Polyclonal anti-Human CCL-17 (TARC)
hAP-5708	Angio Proteomie	50ug	EUR 400

Sheep Polyclonal anti-Human CCL-18 (PARC)
hAP-5709	Angio Proteomie	50ug	EUR 400

Sheep Polyclonal anti-Human CCL-25 (TECK)
hAP-5714	Angio Proteomie	50ug	EUR 400

Anti-Mouse CCL-1 Antibody
103-M320	ReliaTech	100 µg	EUR 399
Description: Mouse CCL1, also known as TCA3, is a member of the CC beta family of chemokines. The human chemokine I309, which shares approximately 42% amino acid (aa) sequence identity, has been assumed to be the homologue of mouse TCA3. Mouse TCA3 and human I309 also share significant sequence homology in the 5' flanking region of their genes and each contain an extra pair of cysteine residues not found in most other chemokines. CCL1 cDNA encodes a 92 aa residue precursor protein with a predicted 23 aa signal peptide that is cleaved to produce a 69 aa mature protein. The sequence of CCL1 contains one potential Nlinked glycosylation site. Mouse CCL1 is found on the distal portion of mouse chromosome 11 in a cluster with MIP1α, MIP1β and JE. CCL1 acts by binding to the seven transmembrane spanning G-protein coupled receptor, CCR8. CCL1 has been shown to chemoattract T cells.

Anti-Mouse CCL-2 Antibody
103-M325	ReliaTech	100 µg	EUR 399
Description: Mouse CCL2 is a member of the β (CC) subfamily of chemokines. The mouse CCL2 gene was initially identified as a plateletderived growth factorinducible gene in mouse fibroblasts. Mouse CCL2 cDNA encodes a 148 amino acid (aa) residue with a putative 23 aa signal peptide that is cleaved to generate the mature protein. Mouse CCL2 shares 82% amino acid sequence identity with rat CCL2. Mouse CCL2 also shares 55% amino acid sequence identity with human MCP1. Compared to human MCP1, mouse CCL2 has a 49 aa residue extension at the carboxyterminus. When a DNA sequence encoding the 125 aa residue of the mature CCL2 protein was expressed in E. coli at R&D Systems, the purified protein had the predicted N-terminus but a mass of 8525 Da. The truncation of most of the C terminal extension could be due either to purification artifact or to posttranslational modification. The truncated recombinant CCL2 has a potency similar to that of human MCP1 in the monocyte chemotaxis assay. Mouse CCL2 has full activity on human cells while human MCP1 has limited activity on mouse cells.

Anti-Mouse CCL-3 Antibody
103-M333	ReliaTech	100 µg	EUR 399
Description: The macrophage inflammatory proteins 1α (or CCL3) and 1β, two closely related but distinct proteins, were originally co purified from medium conditioned by a LPS-stimulated murine macrophage cell line. Mature mouse MIP1α shares approximately 77% and 70% amino acid identity with human MIP1α and mouse MIP1β, respectively. MIP1 proteins are expressed primarily in T cells, B cells, and monocytes after antigen or mitogen stimulation. The MIP1 proteins are members of the β (CC) subfamily of chemokines. Both MIP1α and MIP1β are monocyte chemoattractants in vitro. Additionally, the MIP1 proteins have been reported to have chemoattractant and adhesive effects on lymphocytes, with MIP1α and MIP1β preferentially attracting CD8+ and CD4+ T cells, respectively. MIP1α has also been shown to attract B cells as well as eosinophils. MIP1 proteins have been reported to have multiple effects on hematopoietic precursor cells and MIP1α has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. In the same assays, MIP1β was reported to be much less active. The functional receptor for MIP1α has been identified as CCR1 and CCR5.

Anti-Mouse CCL-4 Antibody
103-M334	ReliaTech	100 µg	EUR 399
Description: CCL4, also known as macrophage inflammatory protein 1 beta (MIP1β), is a 12 kDa β chemokine that is secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells, and pulmonary smooth muscle cells (1, 2). CCL4 attracts a variety of immune cells to sites of microbial infection as well as to other pathologic inflammation such as allergic asthma and ischemic myocardium. A CCL4 deficiency in mice promotes the development of autoantibodies, possibly as a result of compromised regulatory T cell recruitment. CCL4 is secreted from activated monocytes as a heterodimer with CCL3/MIP1α. The first two N-terminal amino acids can be cleaved from human CCL4 by CD26/DPPIV. Both the full length and truncated forms exert biological activity through CCR5, and the truncated form additionally interacts with CCR1 and CCR2. In humans, the ability of CCL4 to bind CCR5 inhibits the cellular entry of Mtropic HIV1 which utilizes CCR5 as a coreceptor. Both forms of CCL4 block HIV1 infection of T cells by inducing the downregulation of CCR5. Mature mouse CCL4 shares 77% and 86% amino acid sequence identity with human and rat CCL4, respectively.

Anti-Mouse CCL-5 Antibody
103-M335	ReliaTech	100 µg	EUR 399
Description: CCL5, also known as RANTES (Regulated upon Activation, Normal T cell Expressed and presumably Secreted), is an 8 kDa βchemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes. Human and mouse RANTES exhibit cross-species activity on human and mouse cells (4). Mature mouse CCL5 shares 100% amino acid (aa) sequence identity with rat CCL5 and 75-88% with canine, cotton rat, feline, and human CCL5. CCL5 is secreted by many cell types at inflammatory sites, and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5. Inflammatory responses can be impaired by the sequestration of CCL5 by the cytomegalovirus protein US28. In humans, CCR5 binding to CCL5 inhibits the infectivity of R5 (M tropic) but not X4 (T tropic) strains of HIV. The two N-terminal residues of CCL5 can be removed by CD26/DPPIV, generating a protein that functions as a chemotaxis inhibitor and more effectively blocks M tropic HIV 1 infection of monocytes. Oligomerization of CCL5 on glycosaminoglycans is required for CCR1mediated leukocyte adhesion and activation as well as CCL5’s interaction with the chemokine CXCL4/PF4. The deposition of CCL5 on activated vascular endothelial cells is crucial for monocyte adhesion to damaged vasculature, but CCL5 oligomerization is not required for the extravasation of adherent leukocytes. CCL5 is upregulated in breast cancer and promotes tumor progression through the attraction of proinflammatory macrophages in addition to its actions on tumor cells, stromal cells, and the vasculature.

Anti-Mouse CCL-6 Antibody
103-M336	ReliaTech	100 µg	EUR 399
Description: Mouse CCL6, a member of the β subfamily of chemokines, was initially identified as a transcript that is induced in bone marrow cells upon stimulation with GM-CSF. A human homologue for mouse CCL6 has not been identified. The mCCL6 cDNA encodes a 116 amino acid residue precursor protein with a hydrophobic signal peptide that is cleaved to yield a 95 amino acid residue mature protein. Compared to other chemokines, mCCL6 has a large N-terminal extension. The expression of CCL6 mRNA has been detected in mouse monocytes and neutrophils, where it is strongly induced upon GM-CSF stimulation. CCL6 expression has also been detected in an IL2-dependent T cell line, where the expression is inhibited following T cell stimulation. Mouse CCL6 expression was also shown to be strongly induced by IL-4 in mouse macrophages. The gene for CCL6 has been mapped to mouse chromosome 11.

Anti-Mouse CCL-8 Antibody
103-M337	ReliaTech	100 µg	EUR 399
Description: CCL8, also known as Monocyte Chemoattractant Protein 2 (MCP2), is an inflammatory CC chemokine that attracts monocytes, eosinophils and basophils. It is produced by many cell types and signals through interactions with CCR1, CCR2, CCR3 and CCR5.

Anti-Mouse CCL-9 Antibody
103-M338	ReliaTech	100 µg	EUR 399
Description: Mouse CCL9/10 (also named MIP1γ and MRP2) is an 11 kDa, secreted, monomeric polypeptide that belongs to the β (or CC) intercrine family of chemokines. Based on its activity and amino acid (aa) sequence, it is further classified as a member of the NC6 or six cysteinecontaining CC subfamily of chemokines. This subfamily contains four Nterminally extended chemokines, two human (CCL15 and CCL23) and two mouse (CCL9 and CCL10). Within this subfamily, there are no humanto rodent interspecies orthologs. Mouse CCL9/10 is synthesized as a 122 aa precursor that contains a 21 aa signal sequence and a 101 aa mature region with six cysteines. As noted, the mature region has an expanded Nterminus relative to other CC family members, and it forms a third intrachain disulfide bond with its two extra cysteines. Mouse CCL9/10 is 75% aa identical to rat CCL9/10. Chemokines are known to undergo proteolytic processing to generate multiple isoforms. NC6 chemokines are usually only marginally active at fulllength, but are converted to highly active forms upon Nterminal truncation. Mature CCL9, in the presence of inflammatory fluids, is naturally truncated by 28, 29 or 30 aa at the Nterminus, generating a highly active, 8 kDa, 71 73 aa CCR1 ligand. In contrast, other CCR1 ligands, CCL3/MIP1α and CCL5/RANTES, lose their potency when proteolytically processed. CCL9/10 is constitutively secreted, and circulates as a fulllength molecule. Any onset of inflammation with subsequent enzyme release may act on local NC6 chemokines, generating early, potent leukocyte chemoattractants.

Mouse Monoclonal anti-human CCL-27 (CTACK)
hAP-0152	Angio Proteomie	100ug	EUR 250

Mouse Monoclonal anti-human CCL-27 (CTACK)
hAP-0152A	Angio Proteomie	100ug	EUR 250

Sheep Polyclonal anti-Human CCL-27 (CTACK)
hAP-5716	Angio Proteomie	50ug	EUR 400

Mouse Monoclonal anti-human CCL-21 (6Ckine)
hAP-0146	Angio Proteomie	100ug	EUR 250

Sheep Polyclonal anti-Human CCL-21 (6Ckine)
hAP-5711	Angio Proteomie	50ug	EUR 400

Mouse Monoclonal anti-human CCL-24 (Eotaxin)
hAP-0149	Angio Proteomie	100ug	EUR 250

Sheep Polyclonal anti-Human CCL-11 (Eotaxin)
hAP-5703	Angio Proteomie	50ug	EUR 400

Sheep Polyclonal anti-Human CCL-24 (Eotaxin)
hAP-5713	Angio Proteomie	50ug	EUR 400

Anti-Human CCL-3 (MIP1 alpha) Antibody
101-M186	ReliaTech	100 µg	EUR 399
Description: The macrophage inflammatory proteins 1α and 1β were originally copurified from medium conditioned by an LPS-stimulated murine macrophage cell line. Human MIP1α refers to the products of several independently cloned cDNAs, including LD78, pL78, pAT464, and GOS19. These cDNAs all code for the same human protein that is a homologue of the murine MIP 1α. Mature MIP1α and MIP1β in both human and mouse share approximately 70% homology at the amino acid level. The MIP1 proteins are members of the β (CC) subfamily of chemokines. Both MIP1α and MIP1β are monocyte chemoattractants in vitro. Additionally, the MIP1 proteins have been reported to have chemoattractant and adhesive effects on lymphocytes, with MIP1α and MIP1β preferentially attracting CD8+ and CD4+ T cells, respectively. MIP1α has also been shown to attract B cells as well as eosinophils. MIP1 proteins have been reported to have multiple effects on hematopoietic precursor cells and MIP1α has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. The functional receptor for MIP1α has been identified as CCR1 and CCR5.

Anti-Human CCL-3 (MIP1 alpha) Antibody
101-M187	ReliaTech	100 µg	EUR 399
Description: The macrophage inflammatory proteins 1α and 1β were originally copurified from medium conditioned by an LPS-stimulated murine macrophage cell line. Human MIP1α refers to the products of several independently cloned cDNAs, including LD78, pL78, pAT464, and GOS19. These cDNAs all code for the same human protein that is a homologue of the murine MIP 1α. Mature MIP1α and MIP1β in both human and mouse share approximately 70% homology at the amino acid level. The MIP1 proteins are members of the β (CC) subfamily of chemokines. Both MIP1α and MIP1β are monocyte chemoattractants in vitro. Additionally, the MIP1 proteins have been reported to have chemoattractant and adhesive effects on lymphocytes, with MIP1α and MIP1β preferentially attracting CD8+ and CD4+ T cells, respectively. MIP1α has also been shown to attract B cells as well as eosinophils. MIP1 proteins have been reported to have multiple effects on hematopoietic precursor cells and MIP1α has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. The functional receptor for MIP1α has been identified as CCR1 and CCR5.

Mouse Monoclonal anti-human CCL-5 (RANTES)
hAP-0155	Angio Proteomie	100ug	EUR 250

Mouse Monoclonal anti-human CCL-5 (RANTES)
hAP-0155A	Angio Proteomie	100ug	EUR 250

Mouse Monoclonal anti-human CCL-13 (MCP-4)
hAP-0137	Angio Proteomie	100ug	EUR 250

Mouse Monoclonal anti-human CCL-16 (HCC-4)
hAP-0140	Angio Proteomie	100ug	EUR 250

Sheep Polyclonal anti-Human CCL-13 (MCP-4)
hAP-5704	Angio Proteomie	50ug	EUR 400

Sheep Polyclonal anti-Human CCL-16 (HCC-4)
hAP-5707	Angio Proteomie	50ug	EUR 400

Mouse Monoclonal anti-human CCL-23 (MPIF-1)
hAP-0148	Angio Proteomie	100ug	EUR 250

Mouse Monoclonal anti-human CCL-23 (MPIF-1)
hAP-0148A	Angio Proteomie	100ug	EUR 250

Sheep Polyclonal anti-Human CCL-14a (HCC-1)
hAP-5705	Angio Proteomie	50ug	EUR 400

Sheep Polyclonal anti-Human CCL-23 (MPIF-1)
hAP-5712	Angio Proteomie	50ug	EUR 400

Mouse Monoclonal anti-human CCL-26 (Eotaxin-3)
hAP-0151	Angio Proteomie	100ug	EUR 250

Sheep Polyclonal anti-Human CCL-26 (Eotaxin-3)
hAP-5715	Angio Proteomie	50ug	EUR 400

Rat Monoclonal anti-mouse CCL-28
mAP-0179	Angio Proteomie	100ug	EUR 250

Human MDC/CCL 22 ELISA KIT
E42EH-288	EnoGene	96T/48T	Ask for price

Mouse Monoclonal anti-human CCL-2 (MCP-1)
hAP-0144	Angio Proteomie	100ug	EUR 250

Mouse Monoclonal anti-human CCL-7 (MCP-3)
hAP-0156	Angio Proteomie	100ug	EUR 250

Mouse Monoclonal anti-human CCL-8 (MCP-2)
hAP-0157	Angio Proteomie	100ug	EUR 250

Sheep Polyclonal anti-human CCL-2 (MCP-1)
hAP-5073	Angio Proteomie	50ug	EUR 400

Rat Monoclonal anti-mouse CCL-3
mAP-0180	Angio Proteomie	100ug	EUR 250

Rat Monoclonal anti-mouse CCL-4
mAP-0181	Angio Proteomie	100ug	EUR 250

Rat Monoclonal anti-mouse CCL-5
mAP-0182	Angio Proteomie	100ug	EUR 250

Rat Monoclonal anti-mouse CCL-6
mAP-0183	Angio Proteomie	100ug	EUR 250

Rat Monoclonal anti-mouse CCL-8
mAP-0184	Angio Proteomie	100ug	EUR 250

Rat Monoclonal anti-mouse CCL-9
mAP-0185	Angio Proteomie	100ug	EUR 250

Rat Monoclonal anti-mouse CCL-6
mAP-0340	Angio Proteomie	100ug	EUR 250

Human RANTES (CCL 5) Recombinant Protein
100-095	ReliaTech	20 µg	EUR 196.35
Description: RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant human RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Human RANTES (CCL 5) Recombinant Protein
100-095S	ReliaTech	5 µg	EUR 92.4
Description: RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant human RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Mouse Monoclonal anti-human CCL-19 (MIP-3 beta)
hAP-0143	Angio Proteomie	100ug	EUR 250

Sheep Polyclonal anti-Human CCL-19 (MIP-3 beta)
hAP-5710	Angio Proteomie	50ug	EUR 400

Mouse Monoclonal anti-human CCL-20 (MIP-3 alpha)
hAP-0145	Angio Proteomie	100ug	EUR 250

Sheep Polyclonal anti-Human CCL-20 (MIP-3 alpha)
hAP-5706	Angio Proteomie	50ug	EUR 400

Nori® Mouse CCL-15 (MIP-5) ELISA Kit
GR117261	Genorise Scientific	96-well	EUR 461

Rat Monoclonal anti-mouse CCL-22 (MDC)
mAP-0175	Angio Proteomie	100ug	EUR 250

Rat Monoclonal anti-mouse CCL-17 (TARC)
mAP-0170	Angio Proteomie	100ug	EUR 250

Rat Monoclonal anti-mouse CCL-25 (TECK)
mAP-0177	Angio Proteomie	100ug	EUR 250

Rat Monoclonal anti-mouse CCL-27 (CTACK)
mAP-0178	Angio Proteomie	100ug	EUR 250

Mouse Monoclonal anti-human CCL-4 (MIP-1 beta)
hAP-1166	Angio Proteomie	100ug	EUR 250

Rat Monoclonal anti-mouse CCL-21 (6Ckine)
mAP-0174	Angio Proteomie	100ug	EUR 250

Rat Monoclonal anti-mouse CCL-11 (Eotaxin)
mAP-0168	Angio Proteomie	100ug	EUR 250

Mouse Monoclonal anti-human CCL-3 (MIP-1 alpha)
hAP-0154	Angio Proteomie	100ug	EUR 250

Mouse Monoclonal anti-human CCL-3 (MIP-1 alpha)
hAP-0154A	Angio Proteomie	100ug	EUR 250

Mouse Monoclonal anti-human CCL-3 (MIP-1 alpha)
hAP-0154B	Angio Proteomie	100ug	EUR 250

Rat Monoclonal anti-mouse CCL-12 (MCP-5)
mAP-0169	Angio Proteomie	100ug	EUR 250

Rat Monoclonal anti-mouse CCL-24 (Eotaxin-2
mAP-0176	Angio Proteomie	100ug	EUR 250

Rabbit anti-Escherichia coli ccl Polyclonal Antibody
MBS7164180-INQUIRE	MyBiosource	INQUIRE	Ask for price

Rat Monoclonal anti-mouse CCL-1 (TCA-3)
mAP-0167	Angio Proteomie	100ug	EUR 250

Rat Monoclonal anti-mouse CCL-2 (MCP-1)
mAP-0172	Angio Proteomie	100ug	EUR 250

Human RANTES (CCL 5, Animal Free) Recombinant Protein
100-095-AF	ReliaTech	20 µg	EUR 229.95
Description: RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant human RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Human RANTES (CCL 5, Animal Free) Recombinant Protein
100-095S-AF	ReliaTech	5 µg	EUR 134.4
Description: RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant human RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Rat Monoclonal anti-mouse CCL-19 (MIP-3 beta)
mAP-0171	Angio Proteomie	100ug	EUR 250

Rat Monoclonal anti-mouse CCL-20 (MIP-3 alpha)
mAP-0173	Angio Proteomie	100ug	EUR 250

Human C-C motif chemokine 2 (CCL-2) ELISA Kit
MBS9305815-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 6725

Human C-C motif chemokine 2 (CCL-2) ELISA Kit
MBS9305815-48StripWells	MyBiosource	48-Strip-Wells	EUR 550

Human C-C motif chemokine 2 (CCL-2) ELISA Kit
MBS9305815-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3420

Human C-C motif chemokine 2 (CCL-2) ELISA Kit
MBS9305815-96StripWells	MyBiosource	96-Strip-Wells	EUR 765

Rat-MIP1γ CCL-9-
QY-E11948	Qayee Biotechnology	96T	EUR 420

Anti- Interleukin-15 (IL-15) Human -BIOTIN Antibody
GWB-66F8CF	GenWay Biotech	0.025 mg	Ask for price

Rat RANTES (CCL 5)
MBS691650-0005mg	MyBiosource	0.005mg	EUR 300

Rat RANTES (CCL 5)
MBS691650-002mg	MyBiosource	0.02mg	EUR 450

Rat RANTES (CCL 5)
MBS691650-5x002mg	MyBiosource	5x0.02mg	EUR 1725

Mouse RANTES (CCL 5)
MBS691610-0005mg	MyBiosource	0.005mg	EUR 300

Mouse RANTES (CCL 5)
MBS691610-002mg	MyBiosource	0.02mg	EUR 450

Mouse RANTES (CCL 5)
MBS691610-5x002mg	MyBiosource	5x0.02mg	EUR 1725

Mouse Anti Human Interleukin-15
MBS140016-05mg	MyBiosource	0.5mg	EUR 440

Mouse Anti Human Interleukin-15
MBS140016-1mg	MyBiosource	1mg	EUR 600

Mouse Anti Human Interleukin-15
MBS140016-5x1mg	MyBiosource	5x1mg	EUR 2375

RABBIT ANTI HUMAN INTERLEUKIN-15
MBS221558-01mg	MyBiosource	0.1mg	EUR 635

RABBIT ANTI HUMAN INTERLEUKIN-15
MBS221558-5x01mg	MyBiosource	5x0.1mg	EUR 2695

Rat CCL-5 ELISA Kit
ERC0240	Abclonal	96Tests	EUR 625.2

Goat CCL-5 ELISA Kit
EGTC0240	Abclonal	96Tests	EUR 625.2

Sheep CCL-5 ELISA Kit
ESC0240	Abclonal	96Tests	EUR 625.2

Mouse CCL-5 ELISA Kit
EMC0240	Abclonal	96Tests	EUR 625.2

Bovine CCL-5 ELISA Kit
EBC0240	Abclonal	96Tests	EUR 625.2

Canine CCL-5 ELISA Kit
ECC0240	Abclonal	96Tests	EUR 625.2

Rabbit CCL-5 ELISA Kit
ERTC0240	Abclonal	96Tests	EUR 625.2

Monkey CCL-5 ELISA Kit
EMKC0240	Abclonal	96Tests	EUR 625.2

Chicken CCL-5 ELISA Kit
ECKC0240	Abclonal	96Tests	EUR 625.2